DKC1 anticorps (AA 171-220)

N° du produit ABIN5540295

L’anticorps Lapin Polyclonal anti-DKC1 a été validé pour WB, IF, ICC et IHC (p). Il convient pour détecter DKC1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DKC1 anticorps (AA 171-220) (ABIN5540295)

Antigène: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DKC1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-DKC1 anticorps

Épitope: AA 171-220

Specificité: The antibody detects endogenous levels of Dyskerin protein. (region surrounding Lys203)

Purification: Affinity Chromatography using epitope-specific immunogen

Immunogène: Synthetic peptide, corresponding to amino acids 171-220 of Human Dyskerin.

Information d'application

Indications d'application: Western blot: 1/500-1/1000. Immunofluorescence : 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 95 % by SDS-PAGE) Aff - Purified

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur DKC1

Antigène: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Autre désignation: dkc1,nola4

Sujet: Dyskerin (NAP57) associates with the chaperone protein Nopp140 and forms a small ribonucleoprotein particle with GAR1 (NOLA1), NHP2 (NOLA2) and Nop10 for the isomerization of uridine to pseudouridine. GAR1, NHP2 and Dyskerin localize to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies. The Dyskerin gene maps to chromosome Xq28. Missense mutations in the Dyskerin gene interfere with normal nuclear localization of Dyskerin and cause Dyskeratosis congenita (DKC). DKC is a rare, X-linked bone marrow disorder characterized by cutaneous hyperpigmentation, dystrophy of the nails, atrophy of the testicles and leukoplakia of the oral mucosa. The GAR1 gene maps to chromosome 4q25 and encodes a 28 kDa protein. The NHP2 gene maps to chromosome 5q35.3 and encodes a 155 amino acid protein.

UniProt: O60832

Pathways: Telomere Maintenance